HumMod

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The best, most complete, mathematical model of human physiology ever created.

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About

In the early 1960’s, Dr. Arthur Guyton started developing mathematical analysis of integrative physiology (Millhorn and Guyton, 1965). Over the next 10 years, Guyton and colleagues (1972) developed a model of cardiovascular physiology with ~150 distinct variables. Guyton used the 1972 model to test a variety of physiological hypotheses, mainly focusing on acute and chronic blood pressure control and the role of the kidney in the long term regulation of blood pressure.

In 1983, with the advent of the personal computer, Coleman and Randall developed a model of human physiology called Human (1983). Human was an extension of the 1972 Guyton, Coleman, and Granger model. Human was expanded into a Windows software package called Quantitative Circulatory Physiology (QCP).

Though QCP was well received, it was limited. The source, including the physiology, was written in C, then compiled into a single executable that prevented adjustment of the physiology. With the help of Dr. Robert Hester, Dr. Coleman created HumMod.

HumMod is the most advanced model of human physiology ever created. The underlying equations are described in XML that is quickly parsed for each new simulation. As a result, HumMod is highly extensible. With over 5,000 variables, and growing, describing human physiology, HumMod is the most complete model of human physiology ever created.

Our products are used by NASA, the EPA, educators, and scientists.

Papers

NASA Use of UMMC’s Software

  • Summers RL, Coleman TG. Computer Systems Analysis of the Cardiovascular Mechanisms of Reentry Orthostasis in Astronauts. Comput Cardiol. 2002;29:521-525.
  • Summers, R.L. and T.G. Coleman. Computer systems analysis of the cardiovascular mechanisms of reentry orthostasis in astronauts. Computers in Cardiology Proceedings 2002. Vol. 29, Washington, D.C., IEEE Computer Society Press, 2002:521-525.
  • Summers, R.L. and T. Coleman. Integrative computer model for the analysis of physiologic adaptations to microgravity. Aviation, Space, Environmental Medicine 75(4):B40 – 188, 2004.
  • Summers RL, Martin DS, Meck JV, Coleman TG. Mechanism of Spaceflight Induced Changes in Left Ventricular Mass. Am J Card 2005; 95:1128-1130.
  • Summers, R., T. Coleman, P. Steven and D.Martin. Systems analysis of the mechanisms of cardiac diastolic function changes after microgravity exposure. Acta Astronautica. 63:722-726, 2008.
  • Summers, R.L. and T.G. Coleman. Computer systems analysis of the cardiovascular mechanisms of reentry orthostasis in astronauts. Computers in Cardiology Proceedings 2002. Vol. 29, Washington, D.C., IEEE Computer Society Press, 2002:521-525.
  • Summers RL, Martin DS, Meck JV, Coleman TG. Computer systems analysis of spaceflight induced changes in left ventricular mass.Comput Biol Med. 2007 Mar;37(3):358-63. Epub 2006 Jun 30.
  • Summers RL, Computer Model for Determination of the Physiologic Correlates of the Impedance Cardiovasculogram Associated with Acute Heart Failure. Comp Cardiol 2007; 34:593-595.
  • Platts SH, Summers RL., Martin DS, Meck JV, Coleman TG. Role for Lower Extremity Interstitial Fluid Volume Changes in the Development of Orthostasis after Simulated Microgravity. NASA Technical Report NTRS: 2008-02-13; Document ID: 20070008090. 2007.
  • Summers RL, Coleman TG, Meck JV. Development of the digital astronaut program for the analysis of the mechanisms of physiologic adaptation to microgravity: Validation of the Cardiovascular Module. Acta Astronautica 2008;63:758-762
  • Summers RL, Coleman TG, Hester RL. An analysis of the interface between lunar habitat conditions and an acclimatized human physiology as defined by the Digital Astronaut Program. Lunar Settlements. Editor: Haym Benaroya. CRC Press 2010; 233-240, ISBN: 9781420083323.
  • Summers RL, Platts S, Myers JG, Coleman TG. Theoretical analysis of the mechanisms of a gender differentiation in the propensity for orthostatic intolerance after spaceflight. Theor Biol Med Model. 2010 Mar 18;7:8.
  • SH Platts, Summers RL, Martin DS, Meck JV, Coleman TG. Effect of Simulated Microgravity on Lower Extremity Interstitial Fluid Volume. Journal of Gravitational Physiology 2010 (in press)

EPA Collaborations

  • Benignus, V.A., T.G. Coleman, C.R. Eklund and E.M. Kenyon. A general physiological and toxicokinetic (GPAT) model for simulating complex toluene exposure scenarios in humans. Tox. Mech. Meth. 16:27-36,2006.
  • Benignus VA, Coleman TG Simulations of exercise and brain effects of acute exposure to carbon monoxide in normal and vascular-diseased persons. Inhal Toxicol. 2010 Apr;22(5):417-26

Use of Simulation Software for Education

  • Abram SR, Hodnett BL, Summers RL, Coleman TG, Hester RL. Quantitative Circulatory Physiology: an integrative mathematical model of human physiology for medical education. Adv Physiol Educ. 2007 Jun;31(2):202-10.
  • *Rodríguez-Barbero A, López-Novoa JM. Teaching integrative physiology using the quantitative circulatory physiology model and case discussion method: evaluation of the learning experience. Adv Physiol Educ. 2008 Dec;32(4):304-11.
  • *Brands MW, Schumacher L. Active learning strategies to teach renal-cardiovascular integration with high student-to-teacher ratios. Adv Physiol Educ. 2009 Dec;33(4):282-5.

* Used our software, but no interaction with authors.

Use of Simulation Software for Research

  • Lohmeier TE, Hildebrandt DA, Warren S, May PJ and Cunningham JT. Recent insights into the interactions between the baroreflex and the kidneys in hypertension. Am J Physiol Regul Integr Comp Physiol 288: R828-R836, 2005.
  • Lohmeier TE, Hildebrandt DA, Dwyer TM, Barrett AM, Irwin ED, Rossing MA and Kieval RS. Renal denervation does not abolish sustained baroreflex-mediated reductions in arterial pressure. Hyper 49: 373-379, 2007.
  • Summers RL, Kevin Ward K, Witten T, Convertino V, Ryan K, Coleman TG, Hester RL. Validation of a Computational Platform for the Analysis of the Physiologic Mechanisms of a Human Experimental Model of Hemorrhage. Circulation 2008:118; S1446-6.
  • Iliescu R, Lohmeier TE. Lowering of blood pressure during chronic suppression of central sympathetic outflow: Insight from computer simulations. Clin Exp Pharmacol Physiol. 2010;37(2):e24-33
  • Burgreen, G.; Hester, R.; Soni, B.; Thompson, D.; Walters, D.K.; Walters, K.B. “DigitalLung: Application of High-Performance Computing to Biological System Simulation,” in Advances in Computational Biology, AEMB (Advances in Experimental Medicine and Biology) Springer Series (2010) Vol. 680, 573-584.

Papers Describing Software

  • Hester RL, Summers RL, Ilescu R, Esters J, Coleman TG. DigitalHuman (DH): An Integrative Mathematical Model of Human Physiology. Proceedings of MODSIM World Conference 2009.
  • Hester RL, Iliescu R, Summers RL, Coleman TG. Systems Biology and Integrative Physiological Modeling. J Physiol. 2010 Dec 6. [Epub ahead of print] PMID: 21135044
  • Hester R, Brown A, Husband L, Iliescu R, Pruett WA, Summers RL and Coleman T (2011). HumMod: A modeling environment for the simulation of integrative human physiology. Front. Physio. 2:12. doi: 10.3389/fphys.2011.00012