HumMod / Summary

Created : 20-Jun-06
Last Modified : 26-Jan-10
Author : Tom Coleman
Copyright : 2006-2010
By : University Of Mississippi Medical Center
Schema : DES V1.0

HumMod / Summary

Created : 20-Jun-06
Last Modified : 26-Jan-10
Author : Tom Coleman
Copyright : 2006-2010
By : University Of Mississippi Medical Center
Schema : DES V1.0

<groupbox>
   <row> 2.0 </row>
   <col> 1.0 </col>
   <high> 5.0 </high>
   <wide> 30.0 </wide>
   <title> Summary </title>

<showvalue>
   <row> 1.4 </row><col> 1.0 </col>
   <name> Kidney-NephronCount.Total </name>
   <format><integer/></format>
   <label> Total </label>
</showvalue>

<showvalue>
   <row> 2.4 </row><col> 1.0 </col>
   <name> Kidney-NephronCount.Total(xNormal) </name>
   <format><decimal> 2 </decimal></format>
   <label> x Normal </label>
</showvalue>

<showvalue>
   <row> 3.4 </row><col> 1.0 </col>
   <name> Kidney-NephronCount.Filtering(%) </name>
   <format><decimal> 1 </decimal></format>
   <label> Filtering (%) </label>
</showvalue>

<infobutton>
  <row> 1.2 </row>
  <col> 26.0 </col>

  <line> A typical nephron count is 2400000. </line>
</infobutton>

</groupbox>



<groupbox>
   <row> 8.0 </row>
   <col> 1.0 </col>
   <high> 7.0 </high>
   <wide> 30.0 </wide>
   <title> Left Kidney Nephrons</title>

<showvalue>
   <row> 1.4 </row><col> 1.0 </col>
   <name> LeftKidney-NephronCount.NumFiltering</name>
   <format><integer/></format>
   <label> Number Filtering </label>
</showvalue>

<showvalue>
   <row> 2.4 </row><col> 1.0 </col>
   <name> LeftKidney-NephronCount.Filtering(xNormal) </name>
   <format><decimal> 4 </decimal></format>
   <label> % Filtering </label>
</showvalue>

<showvalue>
   <row> 3.4 </row><col> 1.0 </col>
   <name> LeftKidney-NephronCount.DamagedNephrons</name>
   <format><integer/></format>
   <label> Damaged Nephrons </label>
</showvalue>

<showvalue>
   <row> 4.4 </row><col> 1.0 </col>
   <name> LeftKidney-NephronCount.DeadNephrons</name>
   <format><integer/></format>
   <label> Dead Nephrons </label>
</showvalue>

<infobutton>
  <row> 1.2 </row>
  <col> 26.0 </col>

  <line> Damaged nephrons still filter, and can be recovered or progress to dead nephrons </line>
  <line> Dead nephrons do not filter </line>
</infobutton>

</groupbox>



<groupbox>
   <row> 16.0 </row>
   <col> 1.0 </col>
   <high> 18.0 </high>
   <wide> 32.0 </wide>
   <title> Left Kidney Damage </title>

<showcurve>
  <row> 1 </row><col> 1.0 </col><high> 7 </high><wide> 30 </wide>
  <leftmargin> 6 </leftmargin>

  <xaxis>
    <name> LeftGlomerulusFiltrate.Pressure</name>
    <label> Pressure </label>
    <scale><min> 50 </min><max> 100 </max><inc> 1 </inc></scale>
  </xaxis>

  <yaxis>
    <label> Damaged </label>
    <scale><min> 0 </min><max> 500000 </max></scale>
  </yaxis>

  <curvename> LeftKidney-NephronCount.PressureEffect </curvename>
</showcurve>

<showgraph>
  <row> 10 </row><col> 1.0 </col><high> 7 </high><wide> 30 </wide>
  <leftmargin> 6 </leftmargin>
  <xaxis>
    <name> System.X </name>
    <label> Time </label>
    <scale><min> 0 </min><max> 2 </max></scale>
  </xaxis>
  <yaxis>
    <yvar>
      <name> LeftKidney-NephronCount.DeadNephrons </name>
      <label> Dead </label>
      <linecolor> BLUE </linecolor>
    </yvar>
    <scale><min> 0 </min><max> 500000 </max></scale>
  </yaxis>
</showgraph>

</groupbox>





<groupbox>
   <row> 1.4 </row>
   <col> 35.0 </col>
   <high> 6 </high>
   <wide> 31.0 </wide>
   <title> Total Nephron #s </title>

<showvalue>
   <row> 1.4 </row><col> 1.0 </col>
   <name> LeftKidney-NephronCount.TotalTotal </name>
   <format><integer/></format>
   <label> Total Nephrons </label>
</showvalue>

<showvalue>
   <row> 2.9  </row><col> 1.0 </col>
   <name> LeftKidney-NephronCount.TotalDamaged </name>
   <format><integer/></format>
   <label> Total Damaged </label>
</showvalue>

<showvalue>
   <row> 4.4 </row><col> 1.0 </col>
   <name> LeftKidney-NephronCount.TotalDead </name>
   <format><integer/></format>
   <label> Total Dead </label>
</showvalue>

</groupbox>



<groupbox>
   <row> 8.0 </row>
   <col> 35.0 </col>
   <high> 7.0 </high>
   <wide> 30.0 </wide>
   <title> Right Kidney Nephrons</title>

<showvalue>
   <row> 1.4 </row><col> 1.0 </col>
   <name> RightKidney-NephronCount.NumFiltering</name>
   <format><integer/></format>
   <label> Number Filtering </label>
</showvalue>

<showvalue>
   <row> 2.4 </row><col> 1.0 </col>
   <name> RightKidney-NephronCount.Filtering(xNormal) </name>
   <format><decimal> 4 </decimal></format>
   <label> % Filtering </label>
</showvalue>

<showvalue>
   <row> 3.4 </row><col> 1.0 </col>
   <name> RightKidney-NephronCount.DamagedNephrons</name>
   <format><integer/></format>
   <label> Damaged Nephrons </label>
</showvalue>

<showvalue>
   <row> 4.4 </row><col> 1.0 </col>
   <name> RightKidney-NephronCount.DeadNephrons</name>
   <format><integer/></format>
   <label> Dead Nephrons </label>
</showvalue>

<infobutton>
  <row> 1.2 </row>
  <col> 26.0 </col>

 <line> Damaged nephrons still filter, and can be recovered or progress to dead nephrons </line>
  <line> Dead nephrons do not filter </line>
</infobutton>

</groupbox>





<groupbox>
   <row> 16.0 </row>
   <col> 35.0 </col>
   <high> 18.0 </high>
   <wide> 32.0 </wide>
   <title> Right Kidney Damage </title>

<showcurve>
  <row> 1 </row><col> 1.0 </col><high> 7 </high><wide> 30 </wide>
  <leftmargin> 6 </leftmargin>

  <xaxis>
    <name> RightGlomerulusFiltrate.Pressure</name>
    <label> Pressure </label>
    <scale><min> 50 </min><max> 100 </max><inc> 1 </inc></scale>
  </xaxis>

  <yaxis>
    <label> Damaged </label>
    <scale><min> 0 </min><max> 500000 </max></scale>
  </yaxis>

  <curvename> RightKidney-NephronCount.PressureEffect </curvename>
</showcurve>

<showgraph>
  <row> 10 </row><col> 1.0 </col><high> 7 </high><wide> 30 </wide>
  <leftmargin> 6 </leftmargin>
  <xaxis>
    <name> System.X </name>
    <label> Time </label>
    <scale><min> 0 </min><max> 2 </max></scale>
  </xaxis>
  <yaxis>
    <yvar>
      <name> RightKidney-NephronCount.DeadNephrons </name>
      <label> Dead </label>
      <linecolor> BLUE </linecolor>
    </yvar>
    <scale><min> 0 </min><max> 500000 </max></scale>
  </yaxis>
</showgraph>

</groupbox>





<radiobuttons>
  <row> 28.5 </row><col> 70 </col>
  <name> RightKidney-NephronCount.SWITCH </name>
  <listname> Common.Switch </listname>
  <label> Hyperfiltration-induced Injury? </label>
</radiobuttons>

<repeatlist>
  <name> tau3 </name>
  <repeat><reps> 20 </reps><stepsize>   2 </stepsize></repeat>
  <repeat><reps> 100 </reps><stepsize>  10 </stepsize></repeat>
</repeatlist>

<slidebar>
  <row> 30 </row><col> 70</col>
  <name> RightKidney-NephronCount.DeadK </name>
  <listname> tau3 </listname>
  <label> Glomerulosclerosis Delay (days) </label>
</slidebar>



<groupbox>
   <row> 14 </row>
   <col> 70 </col>
   <high> 13 </high>
   <wide> 30.0 </wide>
   <title> Afferent Resistance </title>

<showgraph>
  <row> 1.4 </row><col> 1.0 </col><high> 9 </high><wide> 28 </wide>
  <leftmargin> 6 </leftmargin>
  <xaxis>
    <name> System.X </name>
    <label> Time </label>
    <scale><min> 0 </min><max> 2 </max></scale>
  </xaxis>
  <yaxis>
    <yvar>
      <name> RightKidney-AfferentArtery.Resistance </name>
      <label> Right </label>
      <linecolor> BLUE </linecolor>
    </yvar>
    <yvar>
      <name> LeftKidney-AfferentArtery.Resistance </name>
      <label> Left </label>
      <linecolor> GREEN </linecolor>
    </yvar>
    <scale><min> 0</min><max> 0.5 </max></scale>
  </yaxis>
</showgraph>
</groupbox>







<groupbox>
   <row> 2 </row>
   <col> 70 </col>
   <high> 11.2 </high>
   <wide> 30 </wide>
   <title> Total Filtration Rate </title>

<structurename> GlomerulusFiltrate </structurename>

<showvalue>
  <row> 1.4 </row><col> 1.0 </col>
  <name> RightGlomerulusFiltrate.GFR </name>
  <format><decimal> 1 </decimal></format>
  <label> Right GFR </label>
</showvalue>

<showvalue>
  <row> 2.4 </row><col> 1.0 </col>
  <name> LeftGlomerulusFiltrate.GFR </name>
  <format><decimal> 1 </decimal></format>
  <label> Left GFR </label>
</showvalue>

<showgraph>
  <row> 3.4 </row><col> 1 </col><high> 7 </high><wide> 28 </wide>
  <leftmargin> 6 </leftmargin>
  <xaxis>
    <name> System.X </name><label> Time </label>
    <scale><min> 0 </min><max> 2 </max></scale>
  </xaxis>
  <yaxis>
    <yvar><name> RightGlomerulusFiltrate.GFR </name><label> Right </label><linecolor> BLUE </linecolor></yvar>
    <yvar><name> LeftGlomerulusFiltrate.GFR </name><label> Left </label><linecolor> GREEN </linecolor></yvar>
    <scale><min> 30 </min><max> 80 </max></scale>
  </yaxis>
</showgraph>

<infobutton>
  <row> 1.2 </row>
  <col> 26.0 </col>

  <line> A typical GFR is 125 mL/Min. </line>
</infobutton>

</groupbox>




<groupbox>
   <row> 2.5 </row>
   <col> 102 </col>
   <high> 11.2 </high>
   <wide> 35.0 </wide>
   <title> Single Nephron GFR </title>

<structurename> GlomerulusFiltrate </structurename>

<showvalue>
  <row> 1.4 </row><col> 1.0 </col>
  <name> RightGlomerulusFiltrate.SNGFR </name>
  <format><decimal> 7 </decimal></format>
  <label> Right SNGFR </label>
</showvalue>

<showvalue>
  <row> 2.4 </row><col> 1.0 </col>
  <name> LeftGlomerulusFiltrate.SNGFR </name>
  <format><decimal> 7 </decimal></format>
  <label> Left SNGFR </label>
</showvalue>

<showgraph>
  <row> 3.4 </row><col> 5.0 </col><high> 7 </high><wide> 28 </wide>
  <leftmargin> 6 </leftmargin>
  <xaxis>
    <name> System.X </name><label> Time </label>
    <scale><min> 0 </min><max> 2 </max></scale>
  </xaxis>
  <yaxis>
    <yvar><name> RightGlomerulusFiltrate.SNGFR </name><label> Right </label><linecolor> BLUE </linecolor></yvar>
    <yvar><name> LeftGlomerulusFiltrate.SNGFR </name><label> Left </label><linecolor> GREEN </linecolor></yvar>
    <scale><min> 0.000030 </min><max> 0.0001 </max></scale>
  </yaxis>
</showgraph>

<infobutton>
  <row> 1.2 </row>
  <col> 26.0 </col>

  <line> A typical SNGFR is 70 nL/Min. </line>
</infobutton>

</groupbox>







<groupbox>
   <row> 14.0 </row>
   <col> 102 </col>
   <high> 13 </high>
   <wide> 35.0 </wide>
   <title> Glomerular Pressure </title>

<structurename> GlomerulusFiltrate </structurename>

<showvalue>
  <row> 1.4 </row><col> 1.0 </col>
  <name> RightGlomerulusFiltrate.Pressure </name>
  <format><decimal> 1 </decimal></format>
  <label> Right Pressure </label>
</showvalue>

<showvalue>
  <row> 2.4 </row><col> 1.0 </col>
  <name> LeftGlomerulusFiltrate.Pressure </name>
  <format><decimal> 1 </decimal></format>
  <label> Left Pressure </label>
</showvalue>

<showgraph>
  <row> 3.4 </row><col> 1 </col><high> 9 </high><wide> 28 </wide>
  <leftmargin> 6 </leftmargin>
  <xaxis>
    <name> System.X </name><label> Time </label>
    <scale><min> 0 </min><max> 2 </max></scale>
  </xaxis>
  <yaxis>
    <yvar><name> RightGlomerulusFiltrate.Pressure </name><label> Right </label><linecolor> BLUE </linecolor></yvar>
    <yvar><name> LeftGlomerulusFiltrate.Pressure </name><label> Left </label><linecolor> GREEN </linecolor></yvar>
    <scale><min> 50 </min><max> 80 </max></scale>
  </yaxis>
</showgraph>

<infobutton>
  <row> 1.2 </row>
  <col> 28.0 </col>

  <line> Typical Glomerular Pressure is 54  </line>
</infobutton>

</groupbox>



End